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National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad

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Dr. Kalpna Garkhal, Ph.D.

Assistant Professor , Department of Pharmaceutics

Kalpna Garkhal is an Assistant Professor in Pharmaceutics Department at National Institute of Pharmaceutical Education and Research (Ahmedabad). She is a formulation scientist involved in teaching postgraduate and doctoral students, and carrying out advance formulation development research in addressing formulation related challenges. Prior to joining NIPER-A as assistant professor, she was a lead in formulation R&D unit of a pharmaceutical industry for more than a decade. She was instrumental in product development for new chemical entities and repurposed molecule via 505(b1)/505(b2) regulatory routes.

Research Interest

  • Nanocarrier formulation development to address solubility, permeability issue, reduce side effect, and enhance overall bioavailability of drug molecule at the site of action.
  • Tailor the synthesis of polymers and utilize the synthesized polymer for formulation development for targeted delivery.
  • Development of topical particulate, hydrogel formulation(s), microparticles, vesicular carrier etc to address the unmet needs in skin diseases and various biomedical applications.
  • Utilize the expertise of cell-culture technology for screening of formulations for cancer, wound healing application etc.
  • Pre-formulation evaluations, drug excipient compatibility study, process parameters, stability studies and drug substance properties such as particle size, drug physiochemical properties, solid state characterization of drug substance to screen the APIs and their form for better therapeutic efficacy, stability and product development.
  • Biopharm risk assessment of the developed formulations.

Experience

  • May 2022-Present
    Assistant Professor

    NIPER-Ahmedabad, Palaj, Gandhinagar

  • May 2020-Sep 2022
    Team Lead

    Biocon-Bristol Myers Squibb Research Centre, Syngene International Ltd., Bengaluru

  • Oct 2018-May 2020
    Group Lead

    F-R&D, Vyome Therapeutics Ltd., Delhi

  • Oct 2016-Sep 2018
    Scientist -II

    F-R&D, Vyome Biosciences Pvt. Ltd., Delhi

  • Jul 2013-Sep 2016
    Scientist -I

    F-R&D, Vyome Biosciences Pvt. Ltd., Delhi

  • Feb 2012-Jan 2013
    Research Associate

    NIPER, SAS Nagar, Punjab

  • Feb 2009-Jan 2012
    Senior Research Fellow

    NIPER, SAS Nagar, Punjab

  • Feb 2007-Jan 2009
    Junior Research Fellow

    NIPER, SAS Nagar, Punjab

  • Aug 2006-Jan 2007
    Technical Trainee

    F-R&D, Dr. Reddy’s Laboratories Ltd., Hyderabad

Honours

  • SPOT Award for Business Continuity Planning at BBRC, Syngene International Ltd. (2022)
  • SPOT Award for Meeting the Business Needs at BBRC, Syngene International Ltd. (2021)
  • Best Performance Award (1st Position) in Formulation & CMC at Vyome Bisociences Pvt Ltd. (2018)
  • Recognition Award for long service at Vyome Bisociences Pvt Ltd. (2018)
  • Research Associate fellowship under DBT funded project (2012 – 2013)
  • International Travel Support, Department of Science of Technology, Government of India, (July 2011) to attend conference “38th Annual meeting and exposition of controlled release society, National Harbor, Maryland, USA (2021)
  • Partial Travel Grant from INSA, to attend conference “38th Annual meeting and exposition of controlled release society, National Harbor, Maryland, USA (2021)
  • Best Poster Award in 4th Indo-Australian Conference, Vallabh Vidya Nagar, Gujarat(2011)
  • Research Associate fellowship awarded by DST (2011)
  • JRF/SRF fellowship awarded by UGC (2007-2012)
  • Award of Postgraduate Fellowship from Ministry of Chemicals and Fertilizers (2004-06)

    Publications

    1. Sadhasivam, S., Garkhal, K., Singh, H., Yadav, V., Chawrai, S., Ramnane, M., Jain, S., Sardana, K., Ghosh, S. (2020). Newly Developed Anti-Dandruff Regimen, VB-3222, Delivers Enhanced Sensorial and Effective Therapeutic Benefits Against Moderate Adherent Dandruff. Clinical, Cosmetic and Investigational Dermatology. 13, 187–195.
    2. Bodakhe, S., Verma, S., Garkhal, K., Samal, S.K., Sharma, S.S., Kumar, N. (2013). Injectable Photocrosslinkable Nanocomposite based on Poly(Glycerol Sebacate) Fumarate and Hydroxyapatite: Development, Biocompatibility and Bone Regeneration in Rat Calvarial Bone Defect Model. Nanomedicine (Lond). 8(11):1777-95.
    3. Verma, S., Garkhal, K., Mittal, A. and Kumar, N.; Biodegradable Polymers for Emerging Clinical Use in Tissue Engineering, in “Biodegradable polymers in clinical use and clinical development” (Eds. Abraham J. Domb, Neeraj Kumar) John Wiley and Sons, NJ (USA), June 2011, Pp 752. ISBN: 978-0-470-42475-9.
    4. Garkhal K., Mittal A., Verma, S. and Kumar, N. (2011). P-15 functionalized porous microspheres as biomimetic habitats for bone tissue engineering applications. Polym. Adv. Technol. 22, 190-198.
    5. Yenet, W.A., Garkhal K. and Kumar N. (2011). Doxorubicin-loaded (PEG)3-PLA nanopolymersomes: effect of solvents and process parameters on formulation Development and In Vitro Study. Mol. Pharmaceutics. 8, 466–478.
    6. Mittal A., Negi, P., Garkhal, K., Verma, S. and Kumar, N. (2010). Integration of porosity and bio-functionalization to form 3D scaffold: cell culture studies and in vitro degradation. Biomed. Mater. 5, 045001(16pp).
    7. Garkhal, K., Verma, S., Tikoo K., and Kumar, N. (2007). P-15 modified poly(l-lactide-co-e-caprolactone) microspheres as scaffold for tissue engineering. J Biomed. Mater. Res, Part A. 82, 747-756.
    8. Garkhal, K., Verma, S., Johnalagadda, S. and Kumar, N. (2007). Fast degradable Poly(L-lactide-co-ε-caprolactone) microspheres for tissue engineering: Synthesis, characterization and degradation behavior. J Polym. Sci.: Part A: Polym. Chem. 45, 2755-2764.
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