डॉ. बिचिस्मिता साहू, पीएच.डी.
एसोसिएट प्रोफ़ेसर , औषधीय रसायन विज्ञान विभाग
अनुसंधान हित
De novo design and synthesis of peptides, peptoids and nucleic acid based molecules therapeutic and diagnostic applications. Development stimuli-responsive peptide-polymeric scaffolds for biomedical engineering applications. Designing and synthesis of molecular scaffolds and conjugates for Cancer, Metabolic and Neurological Disorder. Development of industrial viable process for API.
Experience
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Dec 2019-Present
Associate Professor
NIPER- Ahmedabad, Palaj, Gandhinagar
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Jan 2019-Dec 2019
Assistant Professor
NIPER- Ahmedabad, Palaj, Gandhinagar
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Oct 2018–Jan 2019
Consultant (Drug Discovery)
KrishBioTech-Kolkata
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Mar 2016- Aug 2018
Manager (R&D-API )
ASolution Pharma, Ambernath, Mumbai
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Jan 2015- Feb 2016
Scientist
Laboratory for advanced research; KET, Mumbai
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Aug 2012-Oct 2014
Senior research scientist
Piramal Enterprises, Mumbai
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Oct 2009-Aug 2011
Research scientist
Piramal Life Science Limited, Mumbai
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Sept 2006-Aug 2009
Post Doctoral Fellow
Carnegie Mellon University, Pittsburgh, USA
Honours
Honours/Awards
- Team award- Piramal Life Science Ltd (PLSL), Mumbai-2011
- Senior Research Fellowship (SRF) sponsored by Council of Scientific and Industrial Research (CSIR), India-2003
- Junior Research Fellowship (JRF) sponsored by Council of Scientific and Industrial Research (CSIR), India-2001
- Qualified All India level Graduate Aptitude Test in Engineering (GATE)-2001
Publications
- Dalvi Tanay, Dewangan Bhaskar, Agarwal Gopal, Shinde Suchita Dattatray, Jain Alok, Srivastava Akshay,Bichismita Sahu. (2021). Design, Synthesis And In-vitro Evaluation Of Fluorinated Triazoles as Multi-Target Directed
Ligands for Alzheimer Disease, Bioorganic & Medicinal Chemistry Letters. 127999. doi.org/10.1016/j.bmcl.2021.127999 - Neeraj Kulkarni, Suchita Dattatray Shinde, Govinda Shivaji Jadhav, Diksha Ramesh AdsareDiksha Ramesh Adsare, Kamya Rao, Mihir Kachhia, Mohit Maingle, Shubham Prakash Patil, Neha Arya, andBichismita Sahu. (2021). Peptide-Chitosan
Engineered Scaffolds for Biomedical Applications, Bioconjugate Chemistry. doi.org/10.1021/acs.bioconjchem.1c00014 - Iulia Sacui , Wei-Che Hsieh , Arunava Manna ,Bichismita Sahu , and Danith H. Ly “Gamma peptide nucleic acids: As orthogonal nucleic acid recognition codes for Organizing molecular self-assembly” J. Am. Chem. Soc., 2015,
137 (26), 8603–8610 - Venkatasubbaiah A Venkatesha, Asavari A Joshi, Magesh Venkataraman, Vinay Sonawane, Prashant K Pandey, Julie Bose, Sarika A Choudhari, Dimple Bhatia, Ankita Srivastava, Vaibhavi Lad, Parkash Gill, Ramachandra Sangana, Tausif Ahmed, Anagha Damre, Vijaykumar
Deore, Bichismita Sahu, Sanjay Kumar, Somesh Sharma and Veena Agarwal “P7170, a novel inhibitor of mTORC1/mTORC2 and Activin Receptor- Like Kinase 1 (ALK1) inhibits the growth of Non Small Cell Lung Cancer” Molecular Cancer
2014, 13, 259 - Sufi M. Thomas; Bichismita Sahu; Srinivas Rapireddy; Raman Bahal; Sarah E. Wheeler; Eva M. Procopio; Joseph Kim; Sonali C. Joyce; Sarah Contrucci; Yun Wang; Kira L. Lathrop; Simon Watkins; Jennifer R. Grandis; Bruce
A. Armitage; Danith H. Ly “Antitumor Effects of EGFR Antisense Guanidine-basedPeptide Nucleic Acids in Cancer Models” ACS Chemical Biology (2013), 8(2), 345-352 - Bichismita Sahu, Guddeangadi N. Gururaja, Anamitra Chatterjee, Bishwajit Ganguly, Shaikh M. Mobin, and Irishi N. N. Namboothiri “Generation and Trapping of a Cage Annulated Vinylidenecarbene and Approaches to Its Cycloalkyne
Isomer” J. Org. Chem. 2012, 77(16), 6998-7004 - BichismitaSahu , Iulia Sacui , Srinivas Rapireddy , Kimberly J. Zanotti , Raman Bahal , Bruce A Armitage , and Danith H. Ly “Synthesis and Characterization of Conformationally- Preorganized, MiniPEG-Containing gammaPNAs
with Superior Hybridization Properties and Water Solubility” J. Org. Chem., 2011, 76 (14), 5614– 5627 - Nilambari Yewalkar, Vijaykumar Deore, Amol Padgaonkar, Sonal monohar,
Bichismita Sahu, Pramod kumar, Archana jalota-Badhwar, Kalpana S. Joshi, someshsharma and sanjaykumar “Development of novel inhibitors targeting HIF-1alpha towards anticancer drug discovery ” Bioorganic and medicinal Chemistry letters, 2010, 20, 6426-6429. - Gaofei He, Srinivas Rapireddy, Raman Bahal,Bichismita Sahu and Danith H. Ly “Strand- Invasion of Extended, Mixed-Sequence B-DNA by ?PNAs” J. Am. Chem. Soc 2009, 131 (34), 12088–12090.
- Bichismita Sahu, Guddeangadi N. Gururaja, Shaikh M. Mobin, and Irishi N. N. Namboothiri “Facile Synthesis of ß-Tribromomethyl and DibromomethylenatedNitroalkanes via Conjugate Addition of Bromoform to Nitroalkenes”
J. Org. Chem., 2009, 74 (6), 2601- 2604 - Bichismita Sahu, Venugopal Chenna, Kira L. Lathrop, Sufi M. Thomas, Gerald Zon, Kenneth J. Livak, and Danith H. Ly “Synthesis of Conformationally Preorganized and Cell- Permeable Guanidine-Based ?-Peptide Nucleic Acids
(?GPNAs)” J. Org. Chem., 2009, 74 (4), 1509-1516 - Bichismita Sahu, R. Muruganantham, I. N. N. Namboothiri; “Synthetic and Mechanistic Investigations on the Rearrangement of 2,3-Unsaturated 1,4-Bis(alkylidene)carbenes to Enediynes” Eur. J. Org. Chem. 2007, 15, 2477-2489