डॉ. पल्लब भट्टाचार्य, पीएच.डी.
एसोसिएट प्रोफ़ेसर , फार्मेकोलॉजी और टोक्सीकोलॉजी विभाग
अनुसंधान हित
- Dr. Bhattacharya investigates the safety and efficacy of intra-arterial stem cell therapy in small and large animal model of ischemic stroke and further deciphering the mechanisms of neuroprotection. He has vast experience in small and large animal surgical skills with a specialization in endovascular delivery in ischemic stroke. He had an advanced training in stem cell biology from Marine Biological Laboratory (MBL), Woods Hole, Massachusetts and Massachusetts Institute of Technology (MIT),USA.
- He has experience in mouse transgenesis and has acquired technical skills necessary to establish transgenic animals( Pronuclear injection, 2 cell injection, blastocyst injection, electroporation of zygotes and embryonic stem cell culture including transfection, selection, cloning and analysis of embryonic stem cell clones) with a latest updates on genome engineering technologies involving CRISPR/Cas9. Presently, he is working with Nobel Laureate Prof. Andrew Schally on the aspects of neuroendocrine regulation in ischemic stroke.
- He is pursuing collaborative research projects with Harvard Medical School, USA, Miller School of Medicine, USA, INSERM, France and Rutgers, USA which includes stroke induced optic neuropathy, strategies for mitochondria protection and exploring the cross talk between mitochondria and endoplasmic reticulum in stroke. His research interest also lies with the regulatory RNA mediated mesenchymal stem cell engineering and nanoparticle based targeted drug delivery to the brain.
Experience
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Dec 2019 - Present
Associate Professor
NIPER-A. India
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July 2016 - Dec 2019
Assistant Professor
NIPER-A. India
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February 2016 - June 2016
Senior Scientist
Stem Cell Biology Laboratory, Department of Biochemistry, Pt. Jawahar Lal Nehru Memorial Medical College, Raipur, India
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June 2012 - January 2016
Post-Doctoral Fellow
Cerebral Vascular Disease Research Laboratory, Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA
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January 2009 – May 2012
Senior Research Fellow
School of Biomedical Engineering, Indian Institute of Technology(BHU), Varanasi, India
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January 2007 – December 2009
Junior Research Fellow
School of Biomedical Engineering, Indian Institute of Technology(BHU), Varanasi, India
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August 2006 – January 2007
Research Fellow, School of Biomedical Engineering
Indian Institute of Technology(BHU), Varanasi, India
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January 2006- July 2006
Research Trainee
Department of Neurophysiology, NIMHANS, Bangalore, India
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Honours
Honours
- Visiting Fellow, Harvard Medical School, Boston, USA
- IBRO teaching faculty for IBRO Neuroscience School.
- Visiting Fellow, University of Michigan, Ann Arbor, USA
- Visiting Fellow, University of Oxford, UK
- Visiting Fellow, National University of Singapore(NUS)
- Extramural Grant reviewer, DST, Govt. of India
- Invited Reviewer of 30 national/international journals
- Ph.D examiner of JNTU, A.P
- Invited Talk at IAN-2016,NBRC,Manesar,Gurgaon,India
- Dr.A PJ Abdul Kalam Young Scientist Invited Talk at IABS-2017
- Invited Talk, IBRO Neuroscience School, NEHU, Shillong,India
Awards
- IBRO Investigator Award,10th World Congress of Neuroscience,Daegu,South Korea
- Paul Dudley White Award by American Heart Association(AHA),USA
- Endowment Fellowship for Stem Cell and Regenerative Medicine Course, Marine Biological Laboratory (MBL), Woods Hole Massachusetts, USA
- Young Investigator Award, Society for Personalized Nano-Medicine, USA
- Young Neurologist Award, European Neurological Society(ENS)
- Top 10% Abstract Award American Heart Association(AHA), USA
- World Federation of Neurology(WFN) International Junior Travel Award
- IBRO International Travel Award
- ISN-CAEN Award for training at USA
- IIT(BHU) Student Achievement Award (2011 and 2012 consecutively)
- BHU Vice Chancellor Award to visit USA.
- TECHNEX-2011 (IIT-BHU) Modex award for most outstanding project
- D.S Kothari Post-Doctoral Fellowship
- UGC JRF/SRF at IIT(BHU), Varanasi
- IIT-GATE (Top state ranker)
- JNU Combined Entrance Exam for Biotechnology (CEEB), DBT Fellowship (Not Availed)
Grants
- US/Miller International Subcontract Research grant(2019-2021)Efficacy of IA versus IV administration of GFP+MSCs following ischemic stroke in animal model.
- DST Grant:(2016-2019); Title: Regulatory non-coding RNA mediated mesenchymal stem cell engineering: A safety and efficacy study in rodent model of cerebral ischemia.Role: Principal Investigator.
- ISN International Return Home Grant (2017-2018); Title: Mitochondrial protection in ischemic stroke by using microRNA mediated engineered stem cells.Role: Principle Investigator.
- DST Grant:(2017-2020); Title: Exploring the molecular mechanism of butter oil enriched nanoformulation in enhancing nasal to brain delivery and its potential role in promoting neurogenesis.Role: Co- Principal Investigator.
- DBT Grant:(2018-2021);Title:Light amplifying carbon quantum dot embedded contact lenses for treatment of night blindness.Role: Co- Principal Investigator.
Consultancies
- Consultant and Coordinator for the Human Stem Cell Clinical Trial at University of Miami Miller School of Medicine by Aldagen, USA
- Consultant and Coordinator for the Human Stem Cell Clinical Trial at University of Miami Miller School of Medicine by Covidien, USA
Publications
- Post-Stroke Impairment of Blood Brain Barrier and Perifocal Vasogenic Edema is Alleviated by Endovascular Mesenchymal Stem Cells Administration: Modulation of PKCδ/MMP9/AQP4 Mediated Pathway, Aishika Datta,Deepaneeta Sarmah,Harpreet Kaur, Antra Chaudhary,Leela
Mounika , Kiran Kalia, Anupom Borah, Dileep R. Yavagal,
Pallab Bhattacharya. Molecular Neurobiology. 2022. - Poonam Jadhav, Mayuri Karande, Abhishek Sarkar, Shubhrakanta Sahu, Deepaneeta Sarmah, Aishika Datta, Antra Chaudhary, Kiran Kalia, Arvind Sharma, Xin Wang,Pallab Bhattacharya. (2022). Glial cells response in stroke.
Cellular and Molecular Neurobiology. 2021. DOI:10.1007/s10571-021-01183-3 - Deepaneeta Sarmah, Aishika Datta, Harpreet Kaur, Kiran Kalia, Anupom Borah, Anne Marie Rodriguez, Dileep R. Yavagal,Pallab Bhattacharya. Sirtuin-1 – mediated NF-κB pathway modulation to mitigate inflammasome signaling
and cellular apoptosis is one of the neuroprotective effects of intra-arterial mesenchymal stem cell therapy following ischemic stroke. Stem Cells Reviews and Reports. 2021. DOI: 10.1007/s12015-021-10315-7. - Aishika Datta, Deepaneeta Sarmah & Pallab Bhattacharya. (2021). Response to Letter to Cell Death Pathways in Ischemic Stroke and Targeted Pharmacotherapy, Translational Stroke Research. doi.org/10.1007/s12975-021-00967-5
- Harpreet Kaur, Deepaneeta Sarmah, Pabbala Veeresh, Aishika Datta, Kiran Kalia, Anupom Borah, Dileep R. Yavagal, andP Bhattacharya. (2021). Endovascular Stem Cell Therapy Post Stroke Rescues Neurons from Endoplasmic
Reticulum Stress-Induced Apoptosis by Modulating Brain-Derived Neurotrophic Factor/Tropomyosin Receptor Kinase B Signaling, ACS Chemical Neuroscience. doi.org/10.1021/acschemneuro.1c00506 - Banashree Chetia Phukan, Ankumoni Dutta, Satarupa Deb, Rubul Saikia, Muhammed Khairujjaman Mazumder, Rajib Paul,P Bhattacharya, Rajat Sandhir & Anupom Borah. (2021). Garcinol blocks motor behavioural deficits by providing
dopaminergic neuroprotection in MPTP mouse model of Parkinson’s disease: involvement of anti-inflammatory response, Experimental Brain Research. doi.org/10.1007/s00221-021-06237-y - P Bhattacharya, Deepaneeta Sarmah, Kunjan R.Dave, Avirag Goswami, Mitsuyoshi Watanabe, Xin Wang, Kiran Kalia, Nikolaus Plesnila, Dileep R.Yavagal, Ofelia Alvarez. (2021). Stroke and stroke prevention in sickle cell
anemia in developed and selected developing countries, Journal of the Neurological Sciences. 117510, doi.org/10.1016/j.jns.2021.117510 - RajibPaula, Joyobrato Nath, Satinath Paul, Muhammed Khairujjaman Mazumder, Banashree Chetiya Phukan, Rubina Roy,P Bhattacharya, Anupom Borah. (2021). Suggesting 7,8-dihydroxyflavone as a promising nutraceutical against
CNS disorders, Neurochemistry International. 148, 105068, doi.org/10.1016/j.neuint.2021.105068 - Deepaneeta Sarmah, Mainak Banerjee, Aishika Datta, Kiran Kalia, Shanta Dhar, Dileep R.Yavagal,P Bhattacharya. (2020). Nanotechnology in the diagnosis and treatment of stroke, Drug Discovery Today. doi.org/10.1016/j.drudis.2020.11.018
- Ankan Sarkar, Deepaneeta Sarmah, Aishika Datta, Harpreet Kaur, Priya Jagtap, Swapnil Raut, Birva Shah, Upasna Singh, Falguni Baidya, Mariya Bohra, Kiran Kalia, Anupom Borah, Xin Wang, Kunjan R Dave, Dileep R Yavagal,P Bhattacharya.
(2020). Post-Stroke Depression: Chaos to exposition, Brain Research Bulletin. DOI: 10.1016/j.brainresbull.2020.12.012 - T.Sylaja PN, Srivastava MVP, Shah S, Bhatia R, Khurana D, Sharma A, Pandian JD, Kalia K, Sarmah D, Nair SS, Yavagal DR, Bhattacharya P. The SARS-CoV-2/COVID-19 pandemic and challenges in stroke care in India. Ann N Y Acad Sci. 2020 May 12:10.1111/nyas.14379.
- K Mazumder, R Paul, P Bhattacharya, A Borah. Neurological sequel of chronic kidney disease: From diminished Acetylcholinesterase activity, to mitochondrial dysfunctions, oxidative stress and inflammation in mice brain.
Nature Scientific Reports 9(1):3097. doi: 10.1038/s41598-018-37935-3.(I.F 4.2) - Dendrimer grafted albumin nanoparticles for the treatment of post cerebral stroke damages: A proof of concept study.Pradhan D, Tambe V, Raval N, Gondalia P,Bhattacharya P, Kalia K, Tekade RK.Colloids Surf B Biointerfaces.
2019 (I.F 4.1) - Endoplasmic reticulum-mitochondria crosstalk: from junction to function across neurological disorders.Veeresh P, Kaur H, Sarmah D, Mounica L, Verma G, Kotian V, Kesharwani R, Kalia K, Borah A, Wang X, Dave KR, Rodriguez AM, Yavagal,Bhattacharya
P.Ann N Y Acad Sci. 2019 (I.F 4.2) - Intra-arterial stem cell therapy modulates neuronal calcineurin and confers neuroprotection after ischemic stroke.Saraf J, Sarmah D, Vats K, Kaur H, Pravalika K, Wanve M, Kalia K, Borah A, Dave KR, Yavagal DR,Bhattacharya
P.Int J Neurosci. 2019 ((I.F 2.1) - Neuroprotective attributes of L-theanine, a bioactive amino acid of tea, and its potential role in Parkinson’s disease therapeutics. Deb S, Dutta A, Phukan BC, Manivasagam T, Justin Thenmozhi A,Bhattacharya P, Paul
R, Borah A. Neurochem Int. 2019((I.F 3.9) - Evolving Evidence of Calreticulin as a Pharmacological Target in Neurological Disorders. Kotian V, Sarmah D, Kaur H, Kesharwani R, Verma G, Mounica L, Veeresh P, Kalia K, Borah A, Wang X, Dave KR, Yavagal DR,Bhattacharya P.
ACS Chem Neurosci. 2019(I.F 3.8) - Madhuri Wanve, Harpreet Kaur, Deepaneeta Sarmah, Jackson Saraf, Kanta Pravalika, Kanchan Vats, Kiran Kalia, Anupom Borah, Dileep R. Yavagal, Kunjan R. Dave, Pallab Bhattacharya. (2018) Therapeutic spectrum of interferon‐β
in ischemic stroke, Journal of Neuroscience Research. https://doi.org/10.1002/jnr.24333 - Kanta Pravalika, Deepaneeta Sarmah, Harpreet Kaur, Kanchan Vats, Jackson Saraf, Madhuri Wanve, Kiran Kalia, Anupom Borah, Dileep R.Yavagal, Kunjan R.Dave,Pallab Bhattacharya. (2018) Trigonelline therapy confers neuroprotection
by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke, Life Sciences. https://doi.org/10.1016/j.lfs.2018.11.014 - Jackson Saraf,Kiran Kalia, Pallab Bhattacharya*,Rakesh Tekade*.Growing Synergy of Nanodiamonds in Neurodegenerative Interventions.Drug Discovery Today (I.F 6.8) Accepted.
- Chengliang Luo, Qiang Yang, Yuancai Liu, Shuanhu Zhou, Jiying Jiang,Russel J. Reiter,Pallab Bhattacharya, Yongchun Cui, Hongwei Yang,He Ma, Jiemin Yao, Sean E. Lawler, Xinmu Zhang, Jianfang Fu, Renato Rozental,Hany Aly, Mark D. Johnson, E. Antonio Chiocca,
Xin Wang. (2018) The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin, in targeting brain injury and liver damage and in maintaining bone health.Free Radical Biology and Medicine,
https://doi.org/10.1016/j.freeradbiomed.2018.10.402 (I.F 6.02) Accepted - Rajib Paul, bAnkumoni Dutta, Banashree Chetia Phukan, Muhammed Khairujjaman Mazumder, Arokiasamy Justin-Thenmozhi, Thamilarasan Manivasagam,, Pallab Bhattacharya, Anupom Borah. (2018) Accumulation of Cholesterol and
Homocysteine in the Nigrostriatal Pathway of Brain Contributes to the Dopaminergic Neurodegeneration in Mice, Neuroscience. 388,347-356. https://doi.org/10.1016/j.neuroscience.2018.07.041(I.F 3.27) - Ami P. Raval, Marc Schatz, Pallab Bhattacharya, Nathan d’Adesky, Tatjana Rundek, W. Dalton Dietrich , Helen M. Bramlett. (2018) Whole body vibration therapy after ischemia reduces brain damage in reproductively senescent
female rats, International Journal of Molecular Sciences. 19(9), 2749 https://doi.org/10.3390/ijms19092749 (I.F 3.6) - Akshant Kumavat, Prachi Dapse, Narendra Kumar, Dinesh Mishra, Rahul Maheshwari,Pallab Bhattacharya, Rakesh Kumar Tekade.(2018) Budding alliance of Nanotechnology in RNA interference therapeutics, Current Pharmaceutical Design. doi: 10.2174/1381612824666180807113948.
- Saraf, Jackson ; Bhattacharya, Pallab; Kalia, Kiran; Borah, Anupom; Sarmah, Deepaneeta ; Kaur , Harpreet ; Dave, Kunjan ; Yavagal, Dileep. A friend or foe: Calcineurin across the gamut of neurological disorders, ACS Central
Science DOI:10.1021/acscentsci.8b00230 (I.F 11.2) - D’ Adesky ND, de Rivero Vaccari JP, P Bhattacharya. et al. Nicotine Alters Estrogen Receptor-Beta-Regulated Inflammasome Activity and Exacerbates Ischemic Brain Damage in Female Rats. International Journal of Molecular
Sciences. 2018;19(5):1330. (I.F 3.6 ) - Muhammed Khairujjaman Mazumder, Rajib Paul, Banashree Chetia Phukan, Ankumoni Dutta, Jayasree Chakrabarty,Pallab Bhattacharya, Anupom Borah. (2018) Garcinol, an effective monoamine oxidase-B inhibitor for the treatment
of Parkinson’s disease, Medical Hypotheses. 117,54-58. https://doi.org/10.1016/j.mehy.2018.06.009 - Sarmah D, Kaur H, Saraf J, Vats K, Pravalika K, Wanve M, Kalia K, Borah A, Kumar A, Wang X, Yavagal DR, Dave KR,P Bhattacharya.Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy. Translational Stroke
Research doi:10.1007/s12975-018-0642-y.(I.F 8.2) - D Sarmah, J Saraf, H Kaur, K Pravalika, R Tekade, A Borah,K Kalia, K Dave,
P Bhattacharya. Stroke Management: An Emerging Role of Nanotechnology Micromachines 8(9), 262, 2017 - R.Paul, A.Choudhury, D C Boruah, R.Devi, M.Choudhury,P Bhattacharya,A Borah. Hypercholesterolemia causes psychomotor abnormalities in mice and alterations in cortico-striatal biogenic amine neurotransmitters: Relevance
to Parkinson’s disease: Neurochemistry International. 108:15-26, 2017. - R Tekade, N Soni, M Tekade, P Kesharwani, P Bhattacharya, R Maheshwari, K Dua, P Hansbro Recent Advances in Oncological Submissions of Dendrimer. Current Pharmaceutical Design. 23(21) 3084-3098, 2017.
- Sharma D, Bhattacharya P, Kalia K, Tiwari V. Diabetic nephropathy: New insights into established therapeutic paradigms and novel molecular targets. Diabetes Res Clin Pract.;128:91-108, 2017
- Atchaneeyasakul K, Guada L, Watanabe M, Bhattacharya P, Raval A, Yavagal D. Large Animal Canine Endovascular Ischemic Stroke Model. Brain Res Bull. 3:127:134-140, 2016
- S Ambekar, P Verma, P Bhattacharya, D Yavagal. Treatment of unruptured brain aneurysm Exp. Rev.of Neurotherapeutics 16:10, 2016