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नेशनल इंस्टीट्यूट ऑफ फार्मास्युटिकल एजुकेशन एंड रिसर्च (नाईपर) - अहमदाबाद

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डॉ. सिद्धेश्वर चौथे, पीएच.डी

सहायक प्रोफेसर , प्राकृतिक उत्पाद विभाग

अनुसंधान हित

  • Bioassay-guided isolation, structure elucidation and synthetic modification of bioactive compounds from medicinal plants.
  • Development of analytical methods for standardization of polyherbal formulations using hyphenated techniques.
  • To establish Q-markers for the quality standards of traditional Ayurvedic /herbal medicines.

Experience

  • March 2020 -Present
    Assistant Professor

    NIPER- Ahmedabad, Palaj, Gandhinagar

  • October 2019-March 2020
    Senior Research Investigator (Team Lead LCMS and HPLC Sections)

    Biocon-BMS R&D Center (BBRC), Syngene International Ltd, Bangalore

  • April 2016-September 2019:
    Research Investigator (Team Lead LCMS and HPLC Sections)

    Biocon-BMS R&D Center (BBRC), Syngene International Ltd, Bangalore

Honours

  • BBRC Bravo Award for developing LCMS based preparative HPLC method development approach (2016).
  • NIH Common Fund Metabolomics Initiative: $1000 travel award to attend the 2nd Annual UAB Workshop on Metabolomics, June 2nd – 5th, 2014.
  • Three GlaxosmithKline Bravo awards for successfully driving various R & D projects (2012-13).
  • Won $8800 Innocentive award for solving the Innocentive challenge entitled “Process Mass Intensities.” Sponsored by Merck Pharmaceutical Inc, 2010.
  • Won $1000 Innocentive award for solving the Innocentive challenge entitled “Novel Sources for Extraction of Xanthophyll Carotenoids”(2010).
  • Senior Research Fellowship, Council of scientific and industrial research (CSIR), Ministry of Science and Technology, India (2010-12).
  • Senior Research Fellowship, Department of biotechnology (DBT), Ministry of Science and Technology, India (2008-2010).
  • Junior Research Fellowship, Department of biotechnology (DBT), Ministry of Science and Technology, India (2006-2008).
  • Master program Fellowship, Graduate aptitude test in engineering (GATE) conducted by IIT Madras (2002).

Publications

  • Meena U. Rajagopal ,Shivani Bansal, Prabhjit Kaur, Shreyans K. Jain ,Tatiana Altadil, Charles P. Hinzman, Yaoxiang Li, Joanna Moulton, Baldev Singh, Sunil Bansal,
    Siddheshwar Kisan Chauthe, Rajbir Singh, Partha P. Banerjee, Mark Mapstone, Massimo S. Fiandaca, Howard J. Federoff, Keith Unger, Jill P. Smith and Amrita K. Cheema. (2021). TGFβ Drives Metabolic Perturbations during Epithelial
    Mesenchymal Transition in Pancreatic Cancer: TGFβ Induced EMT in PDAC. Cancers,13 (24), 6204. https://doi.org/10.3390/cancers13246204.
  • Parusu Kavya Teja, Jinal Mithiya, Abhijeet S.Kate, Khemraj Bairwa,
    Siddheshwar K Chauthe.     (2021). Herbal nanomedicines: Recent advancements, challenges, opportunities and regulatory overview, Phytomedicine. 153890. https://doi.org/10.1016/j.phymed.2021.153890.
  • Teja, P. K.; Mithiya, J.; Kate, A. S.; Bairwa, K.;
    Chauthe, S.K.     (2021) Herbal Nanomedicines: Recent Advancements, Challenges, Opportunities and Regulatory Overview. Phytomedicine, 153890. https://doi.org/https://doi.org/10.1016/j.phymed.2021.153890
  • Teja, P. K.; Patel, P.; Bhavsar, D.; Bindusri, C.; Jadhav, K.;
    Chauthe, S.K.     (2021) Traditional Uses, Phytochemistry, Pharmacology, Toxicology and Formulation Aspects of Glycosmis Species: A Systematic Review. Phytochemistry, 190, 112865. https://doi.org/https://doi.org/10.1016/j.phytochem.2021.112865
  • Singh, D. K.; Chauthe, S.K.; Anjanappa, P.; Kumar, S.; Arulraj, R. A.; Gajjela, R.; Mohammed, N.; Kanthappa, V. T.; Karmakar, A.; Gupta, A. K.; Bajpai, L.; Bagadi, M.; Mathur, A. (2021) Synthesis and Characterization
    of a Series of N,N′-Substituted Urea Derivatives by Using Electrospray Ionization Tandem Mass Spectrometry: Differentiation of Positional Isomers. Rapid Commun. Mass Spectrom, 35 (19), 1–12. https://doi.org/10.1002/rcm.9161
  • Rajagopal, M. U.; Bansal, S.; Kaur, P.; Jain, S. K.; Altadil, T.; Hinzman, C. P.; Li, Y.; Moulton, J.; Singh, B.; Bansal, S.;Chauthe, S.K.; Singh, R.; Banerjee, P. P.; Mapstone, M.; Fiandaca, M. S.; Federoff, H. J.;
    Unger, K.; Smith, J. P.; Cheema, A. K. (2021) TGFβ Drives Metabolic Perturbations during Epithelial Mesenchymal Transition in Pancreatic Cancer: TGFβ Induced EMT in PDAC. Cancers, https://doi.org/10.3390/cancers13246204
  • Shyamsundar, M.; Chauthe, S.K.; Subramani, L.; Subbaiah, M. A. M.; Gupta, A.; Bajpai, L.; Bagadi, M.; Mathur, A. (2021) Separation and Preparative Purification of L‐and D‐valine Ester: Diastereomeric Conjugates of Atazanavir
    Using a Combination of 2‐propanol and Acetonitrile in Reversed‐phase High‐performance Liquid Chromatography. Sep. Sci. Plus, 4 (1), 16–23. https://doi.org/10.1002/sscp.202000046
  • Asokan, K.; Shaikh, K.M.; Tele, S.S ;
    Chauthe, S.K,     Ansar, S.; Vetrichelvan, M.; Nimje, R.; Gupta, A.; Gupta, A.K.; Sarabu, R.; Wu, D.-R.; Mathur, A.; Bajpai, L., Applications of 2, 2, 2 trifluoroethanol as a versatile co-solvent in supercritical fluid chromatography for purification of
    unstable boronate esters, enhancing throughput, reducing epimerization and for additive free purifications, J. Chromato. A, 2018, 1531, 22-130.
  • Tiwari, R.; Ahire, D.; Kumar, H.; Sinha, S.;
    Chauthe, S.K,     Subramanian, M.; Iyer, R.; Sarabu, R.; Bajpai, L., Use of hybrid capillary tube setup on 400MHz NMR for quantitation of crucial low quantity metabolites using aSICCO signal, Drug Metab Dispos. 2017, 45, 1215-1224.
  • Laiakis, E.C.; Pannkuk, E.L.;
    Chauthe, S.K,     Wang, Y.-W.; Lian, M. Mak, T.D.; Barker, C.A.; Astarita, G.; Fornace, A., A serum small molecule biosignature of radiation exposure from total body irradiated patients, J. Proteome Res., 2017, 16, 3805–3815.
  • Goudarzi, M.; Chauthe, S.K, Strawn, S.J.; Weber, W.M.; Brenner, D.J.; Fornace, A.J., Quantitative analysis of urinary citrulline and calcitroid acid in mice after external beam gamma-irradiation
    or exposure to internal emitters, Int. J. Mol. Sci. 2016, 17, 782.
  • Chauthe, S.K,
    Mahajan, S.; Rachamalla, M.; Tikoo, K.; Singh, I. P. Synthesis and evaluation of linear furanocoumarins as potential anti-breast and anti-prostate cancer agents, Med. Chem. Res. 2015, 24, 2476-84.
  • Chauthe, S.K,
    Bharate, S. B.; Periyasamy, G.; Khanna, A.; Bhutani, K. K.; Mishra, P. D.; Singh, I. P. One pot synthesis and anticancer activity of dimeric phlorolglucinols, Bioorg. Med. Chem. Lett. 2012, 22, 2251-2256.
  • Chauthe, S.K,; Sharma, R. J.; Gupta, R. C.; Singh, I. P. qNMR: An applicable method for standardization of Indian medicinal plants extracts and their herbal formulations, Phytochem. Anal.
    2012, 23, 689-96.
  • Chauthe, S.K,
    Bharate, S. B.; Sabde, S.; Mitra, D.; Bhutani, K. K.; Singh, I. P. Biomimetic synthesis and anti-HIV activity of dimeric phloroglucinols. Bioorg. Med. Chem. 2010, 18, 2029-2036.
  • Sabde, S.; Bodiwala, H. S.; Karmase, A.; Deshpande, P. J.; Kaur, A.; Ahmed, N.;Chauthe, S.K,Brahmbhatt, K. G.; Phadke, R. U.; Mitra D.; Bhutani, K. K. and Singh, I. P. Anti HIV activity of
    Indian medicinal plants, J. Nat. Med. 2011, 65, 662-669
  • Bharate, S. B.; Khan, S. I.; Yunus, N. A. M.;
    Chauthe, S.K,     Jacob, M. R.; Tekwani, B. L.; Khan, A.; Singh, I. P. Antiprotozoal and antimicrobial activities of O-alkylated and formylatedacylphloroglucinols. Bioorg. Med. Chem. 2007, 15, 87–96.
  • Bharate S. B.; Chauthe, S.K, Bhutani K. K.; Singh I. P. An efficient two-step synthesis of jensenone. Synthesis of analogues and evaluation as antioxidants. Aust. J. Chem. 2005, 58, 7, 551-555.
  • Singh, I. P.; Chauthe, S.K, Small molecule HIV entry inhibitors-Part I: Chemokine receptor antagonists – 2004-2010, Expert Opin. Ther. Pat. 2011, 21, 227–269.
  • Singh, I. P.; Chauthe, S.K, Small molecule HIV entry inhibitors-Part II: Attachment and fusion inhibitors – 2004-2010, Expert Opin. Ther. Pat. 2011, 21, 399–416.
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